{"product_id":"abcam-ab262935","title":"Abcam, ab262935, Anti-nSMase-3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal nSMase-3 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SMPD4 aa 550-700.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SMPD4 aa 550-700. The exact immunogen used to generate this antibody is proprietary information.Q9NXE4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNSMase-3 also known as neutral sphingomyelinase 3 is an important enzyme that regulates sphingolipid metabolism. This enzyme with a molecular mass of approximately 95 kDa hydrolyzes sphingomyelin to produce ceramide a lipid signaling molecule. Expression of nSMase-3 occurs in various tissues with higher levels observed in brain and heart tissue. It plays a role in cellular membrane dynamics and signaling contributing to the regulation of stress responses and apoptosis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeutral sphingomyelinase 3 participates in modulating ceramide production in cellular processes. It acts as an important regulator of membrane microdomain composition influencing cellular signaling pathways. nSMase-3 also integrates into protein complexes involved in vesicular transport and trafficking. It impacts cellular responses to external signals aiding in processes like apoptosis and stress responses. Its activity modulates how cells adapt and manage environmental stressors.\u003cbr\u003e\nPathways\u003cbr\u003e\nSphingolipid metabolism involves nSMase-3 significantly. It is part of the ceramide signaling pathway that underpin cellular responses to stress. This pathway interacts with proteins like PKC (protein kinase C) and influences apoptosis and cell growth. The enzyme's involvement in signaling pathways allows it to integrate with proteins like TNF receptor-associated factors during stress-induced cellular responses impacting signal transduction processes.\u003cbr\u003e\nAbnormal nSMase-3 activity links to neurodegenerative diseases and cardiac disorders. Changes in its enzyme activity influence diseases such as Alzheimer's where ceramide accumulation is a factor. The enzyme also connects to proteins like the beta-amyloid impacting plaque formation in neurodegenerative conditions. Furthermore nSMase-3 affects cardiac disorders by altering ceramide levels which in turn modulates heart cell death pathways potentially influencing cardiovascular diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854116573353,"sku":"ab262935","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab262935","provider":"Iright","version":"1.0","type":"link"}