{"product_id":"abcam-ab264403","title":"Abcam, ab264403, Anti-FBSH antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal FBSH antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human FBRS aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human FBRS aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9HAH7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFollicle-Stimulating Hormone (FSH) also known as Follitropin is a glycoprotein with a molecular mass of approximately 30 kDa. FSH is secreted by the anterior pituitary gland and is composed of two subunits: a common alpha subunit and a unique beta subunit. This hormone plays an important mechanical role in regulating reproductive processes. It stimulates the growth and development of ovarian follicles in females and supports spermatogenesis in males by acting on Sertoli cells. The expression of FSH mainly occurs in cells of the gonads and the pituitary gland.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFSH influences reproductive and endocrine functions. It is part of the pituitary-gonadal axis acting as a pivotal hormone that regulates gamete production and hormonal secretions. Together with Luteinizing Hormone (LH) it forms an important hormonal complex involved in the reproductive cycle. FSH binds to specific receptors on the ovaries and testes initiating intracellular signaling pathways that promote follicular growth estrogen production in females and sustenance of Sertoli cell-mediated actions in males.\u003cbr\u003e\nPathways\u003cbr\u003e\nFSH participates prominently in the reproductive hormone cascade and the hypothalamic-pituitary-gonadal (HPG) axis. It interacts with the pathway controlling the menstrual and estrous cycles in females and spermatogenesis in males. The release of FSH responds to Gonadotropin-Releasing Hormone (GnRH) stimulation which also regulates LH. The coordinated actions of FSH and related family proteins such as Inhibin and Activin ensure proper feedback mechanisms are maintained for balanced reproductive health.\u003cbr\u003e\nFSH relates closely to conditions like polycystic ovary syndrome (PCOS) and hypogonadism. PCOS often presents with abnormal levels of FSH and its counterpart LH disrupting normal ovarian function. In males low levels of FSH can lead to hypogonadism characterized by insufficient testosterone production and impaired spermatogenesis. The disease connections demonstrate FSH’s critical involvement within broader reproductive disorders with significant interactions with LH and testosterone further linking these hormonal interactions to disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848589529257,"sku":"ab264403","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab264403","provider":"Iright","version":"1.0","type":"link"}