{"product_id":"abcam-ab264484","title":"Abcam, ab264484, Anti-Chondroitinase ABC I antibody [HL2010] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nMouse Recombinant Monoclonal Chondroitinase ABC I antibody. Carrier free. Suitable for WB, I-ELISA and reacts with Proteus vulgaris samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL2010,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Proteus vulgaris,\u003cbr\u003e\nApplications:WB, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab264484 is the carrier-free version of\u003cbr\u003e\nab256485\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nChondroitinase ABC I also known as ChABC or Chondroitinase breaks down chondroitin sulfate and dermatan sulfate chains which are components of proteoglycans in the extracellular matrix. This enzyme with an approximate mass of 120 kDa originates from the bacterium Proteus vulgaris. Researchers often focus on its enzymatic function due to its ability to digest glycosaminoglycans thereby reducing inhibitory structures in the nervous system. Chondroitinase ABC I is not endogenously expressed in human tissue but its application involves tissue cultures and animal models.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme plays a significant role in modulating the extracellular matrix by cleaving glycosaminoglycans removing barriers that can hinder cell regeneration. This activity indicates its potential for enhancing neural plasticity and aiding tissue repair particularly within the central nervous system. Although not requiring a complex for its activity Chondroitinase ABC I operates effectively in environments where its substrate is present facilitating processes important for remodeling the extracellular matrix.\u003cbr\u003e\nPathways\u003cbr\u003e\nChondroitinase ABC I contributes to the neural regeneration and repair pathway by altering the extracellular environment. Its function complements the actions of matrix metalloproteinases which also modify the extracellular matrix. The modulation of inhibitory proteoglycans aligns Chondroitinase ABC I with neuroplasticity pathways influencing neurite outgrowth and synaptic remodeling. This activity creates potential for pathways aiming at recovery from neural injuries and degeneration.\u003cbr\u003e\nThe use of Chondroitinase ABC I demonstrates potential therapeutic applications for conditions like spinal cord injury and multiple sclerosis. By facilitating neural repair and overcoming chondroitin sulfate proteoglycan-induced inhibition it offers promise in these challenging conditions. In the context of spinal cord injury Chondroitinase ABC I interacts functionally with proteins related to axonal regeneration such as Nogo receptor supporting its regenerative capability. In multiple sclerosis the enzyme's ability to alter the extracellular matrix may relieve some of the inhibitory effects faced during remyelination efforts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854642237609,"sku":"ab264484","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab264484","provider":"Iright","version":"1.0","type":"link"}