{"product_id":"abcam-ab265003","title":"Abcam, ab265003, Human DSTYK (RIPK5) knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nDSTYK KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 1 and 1 bp insertion in exon 1 and 5 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 1 and 1 bp insertion in exon 1 and 5 bp deletion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-DSTYK, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRIPK5 also known as Receptor-Interacting Protein Kinase 5 is an important signaling molecule with a molecular mass of approximately 78 kDa. It belongs to the RIP kinase family characterized by a serine\/threonine kinase domain. RIPK5 is expressed in a diverse range of tissues with higher expression levels noted in the brain and spleen. This distribution suggests a role in both neural function and immune response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRIPK5 functions as part of a larger protein complex involved in cellular stress responses. It contributes to the modulation of apoptosis and necroptosis two forms of programmed cell death. While RIPK5 itself does not initiate these processes its kinase activity modifies other proteins in the complex altering their function and the outcome of cell death pathways. This highlights RIPK5's integrative role in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nRIPK5 participates in key signaling networks like the TNF receptor and NF-κB pathway. It interacts closely with proteins such as TAK1 and TRAF2 mediating downstream signaling cascades that affect inflammation and immune response. Through these interactions RIPK5 can influence cell survival differentiation and inflammatory responses impacting various physiological processes.\u003cbr\u003e\nResearch has linked RIPK5 to neurological disorders such as Alzheimer's disease and Parkinson's disease. Its association with proteins like tau and α-synuclein in these conditions suggests a potential role in neurodegeneration possibly through pathways that misregulate cell death or inflammatory responses. Understanding RIPK5's involvement in these diseases could provide insight into disease progression and opportunities for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845147807913,"sku":"ab265003","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265003","provider":"Iright","version":"1.0","type":"link"}