{"product_id":"abcam-ab265218","title":"Abcam, ab265218, Human NOMO2 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nNOMO2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 1 and 1 bp insertion in exon 1 and 2 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 1 and 1 bp insertion in exon 1 and 2 bp insertion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-NOMO2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNOMO2 also known as Nodal Modulator 2 or pM5 is an endoplasmic reticulum membrane protein with a molecular mass of approximately 130 kDa. It functions mechanically as a part of the Nomo family which includes homologous proteins such as NOMO1 and NOMO3. The NOMO2 protein plays a critical role in the suppression of Nodal signaling. This protein is ubiquitously expressed but with higher levels observed in tissues including the pancreas and testis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNOMO2 modulates essential signaling pathways during early embryonic development. It acts as part of a larger protein complex known as the Nicalin-NOMO complex which modulates Nodal signaling. This signaling is important for pattern formation and axis specification during embryogenesis. By participating in these processes NOMO2 contributes to the regulation of cellular differentiation and proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nNOMO2 operates within the TGF-beta signaling pathway an important player in cell growth and differentiation. It directly influences Nodal signaling a branch of the TGF-beta pathway by interacting with other proteins like Nicalin and TMEM147. Through its involvement in these pathways NOMO2 helps coordinate cellular responses and genetic transcription important for embryonic patterning and organogenesis.\u003cbr\u003e\nNOMO2 is linked to congenital disorders resulting from disrupted embryonic development. Alterations in NOMO2 function can contribute to conditions such as congenital heart defects. Additionally NOMO2's connection with the TGF-beta pathway may influence cancer progression as this pathway frequently interacts with oncogenes and tumor suppressors like SMAD proteins that are dysregulated in cancer.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845147152553,"sku":"ab265218","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265218","provider":"Iright","version":"1.0","type":"link"}