{"product_id":"abcam-ab265324","title":"Abcam, ab265324, Human ZNF692 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nZNF692 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 2 and 1 bp insertion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 2 and 1 bp insertion in exon 2,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ZNF692, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZNF692 also known as Zinc Finger Protein 692 functions mechanically as a transcription factor involved in gene expression. This protein weighing approximately 70 kDa contains zinc finger motifs that facilitate its binding to DNA sequences. ZNF692 is expressed in various tissues with significant expression in the liver and kidney. Its role in binding DNA suggests that it might influence the transcription of specific genes by regulating their expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZNF692 interacts with other nuclear proteins to perform its functions effectively. It acts as part of a complex that regulates transcriptional networks influencing cellular responses and development. This zinc finger protein plays an essential role in cellular differentiation processes and might be critical in the maintenance of cellular identity. ZNF692's interaction with other proteins can modulate its activity within the cell nucleus affecting the transcriptional regulation of genes involved in cell growth and division.\u003cbr\u003e\nPathways\u003cbr\u003e\nZNF692 integrates into several key biological networks influencing gene expression. It associates with pathways such as the Wnt signaling pathway which is vital for cell proliferation differentiation and apoptosis. ZNF692's function within the Wnt pathway may involve interactions with β-catenin a central protein in this signaling cascade. Another pathway where ZNF692 might have a role is the MAPK pathway where it could modulate signal transduction processes that affect cellular responses to external stimuli.\u003cbr\u003e\nAberrant expression or mutations of ZNF692 have potential links to liver disease and certain types of cancers. In liver disease altered ZNF692 activity might disrupt normal liver function and gene expression. In cancer ZNF692 could be associated with genes controlling cell division and survival possibly influencing tumor progression. The dysregulation of proteins like β-catenin in these diseases suggests that ZNF692's interactions in these pathways could be therapeutically relevant for understanding and targeting these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845151543465,"sku":"ab265324","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265324","provider":"Iright","version":"1.0","type":"link"}