{"product_id":"abcam-ab265465","title":"Abcam, ab265465, Human ANKRD17 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nANKRD17 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ANKRD17, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nANKRD17 also known as Ankyrin Repeat Domain-containing protein 17 performs key mechanical roles within the cell. This protein weighs around 260 kDa. ANKRD17 is found throughout the human body with notable expression in the brain and liver. It functions importantly in the regulation of cell cycle and nucleocytoplasmic transport through its ankyrin repeat domains which allow interactions with other proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANKRD17 engages in processes such as gene expression regulation and immune response. It is a member of protein complexes involved in these pathways. ANKRD17 modulates the transcriptional activity of certain genes and plays a part in antiviral response due to its role in signaling pathways that detect viral infections. These roles reflect its significance in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nANKRD17 participates mainly in the NF-κB and p53 signaling pathways. In the NF-κB pathway ANKRD17 interacts with proteins like IκB facilitating processes that control inflammation and immune responses. In the p53 pathway it associates with the p53 protein regulating cell cycle arrest and apoptosis. Its involvement in these pathways highlights its function in monitoring cell integrity and response to stress or damage.\u003cbr\u003e\nANKRD17 has associations with hepatocellular carcinoma and viral infections. It interacts with tumor suppressor proteins like p53 where its altered function can contribute to cancer development by affecting cell cycle control and apoptosis. In viral infections such as influenza ANKRD17's role in immune signaling can impact the body's ability to effectively respond to pathogens. Understanding these connections emphasizes its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845205708969,"sku":"ab265465","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265465","provider":"Iright","version":"1.0","type":"link"}