{"product_id":"abcam-ab265499","title":"Abcam, ab265499, Human ELL2 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nELL2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 1 and 26 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 1 and 26 bp insertion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ELL2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nELL2 also known as Eleven Nineteen Lysine-rich Leukemia 2 is a protein involved in transcriptional regulation. This protein has a molecular mass of approximately 76 kDa. ELL2 is expressed in various tissues including both lymphoid and non-lymphoid origins. It functions as an elongation factor for RNA polymerase II modulating the rate of transcription elongation by directly interacting with the transcription machinery.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nELL2 plays a significant role in RNA processing and maturation. It is a part of the ELL complex and works alongside other proteins that facilitate the transition from transcription initiation to elongation. By promoting RNA synthesis and elongation efficiency ELL2 is linked with gene expression regulation particularly within the adaptive immune system. This protein helps in optimizing the output of genes active in immune cells contributing to the functionality and differentiation of these cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nELL2 participates actively in the transcription regulation pathway and its interaction with RNA polymerase II. The protein influences gene expression regulation by enhancing transcriptional elongation. ELL2 is also involved in pathways associated with the immunoglobulin production process. It interacts with other proteins such as ELL1 and pTEFb which further coordinate the elongation steps of transcription thereby impacting overall gene expression in immune-related pathways.\u003cbr\u003e\nELL2 associates with multiple myeloma and immunodeficiency disorders. Its dysfunction can impact immunoglobulin transcription in plasma cells potentially leading to aberrant immunoglobulin production—an element in the pathogenesis of multiple myeloma. The association of ELL2 with RNA polymerase II and its partners like pTEFb sheds light on its role in these conditions as faulty regulation of transcription elongation can lead to abnormal cell proliferation and survival characteristic of certain cancers and immune disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845165174953,"sku":"ab265499","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265499","provider":"Iright","version":"1.0","type":"link"}