{"product_id":"abcam-ab265568","title":"Abcam, ab265568, Human TSSK3 (TSSK-3) knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nTSSK3 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp deletion in exon 2,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-TSSK3, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTSSK-3 also known as Testis-Specific Serine Kinase 3 is a protein kinase that performs phosphorylation. It has a mass of approximately 37 kDa. This protein is primarily expressed in the testis where it plays a role in testicular function. TSSK-3 belongs to the family of serine\/threonine kinases and is involved in signaling processes specific to sperm development and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSerine\/threonine kinase activities of TSSK-3 influence spermatogenesis. TSSK-3 engages in the regulation of important processes like cell cycle control and differentiation required for sperm maturation. Although TSSK-3 does not form part of an extensive complex its function notably impacts cellular activities during sperm development.\u003cbr\u003e\nPathways\u003cbr\u003e\nTSSK-3 function integrates within the MAPK signaling pathway and the cell cycle regulation pathway. In the MAPK signaling pathway it interacts with other kinases and signaling molecules that modulate testicular functions and sperm maturation. Within cell cycle regulation TSSK-3 associates with proteins that govern cell division and polarization such as CDKs (Cyclin Dependent Kinases).\u003cbr\u003e\nTSSK-3 links closely to male infertility and defects in spermatogenesis. Mutations or dysregulation in TSSK-3 activity can impact fertility by impairing sperm development. Additionally TSSK-3 may co-function with proteins like Aurora Kinases which also influence cell cycle processes contributing to testicular anomalies affecting fertility potential.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845198401705,"sku":"ab265568","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265568","provider":"Iright","version":"1.0","type":"link"}