{"product_id":"abcam-ab265648","title":"Abcam, ab265648, Human FAM98A knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nFAM98A KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp deletion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-FAM98A, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFAM98A also known as Family with Sequence Similarity 98 Member A is a cytoplasmic protein with a mass of approximately 26 kDa. This protein shows expression in various tissues including the brain and liver. It functions mechanically in processes involving RNA contributing to RNA-binding activities although the specific details of its RNA interactions remain to be fully understood.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein acts within a larger multi-protein complex affecting cellular and molecular functions that are important for proper cell regulation. It participates in processes like gene expression modulation although the precise scope of its biological roles is still under investigation. FAM98A also appears to engage in interactions influencing cell cycle regulation which highlights its importance in maintaining cell stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nFAM98A integrates into significant cellular pathways such as TOR signaling and may also influence mitotic processes. It interacts with proteins like the RACK1 scaffolding protein suggesting a role in protein translation and signaling pathways. These interactions position FAM98A within important circuits that oversee cell growth and proliferation.\u003cbr\u003e\nChanges in FAM98A function or expression could contribute to cancer and neurological disorders reflecting its involvement in cell cycle and regulatory processes. For instance in certain cancers its altered interaction with proteins like RACK1 may impact tumor progression. Meanwhile in neurological disorders disruptions in its RNA-binding role might link to dysregulation of neuronal functions. Further research could open additional insights into these associations.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845196468393,"sku":"ab265648","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265648","provider":"Iright","version":"1.0","type":"link"}