{"product_id":"abcam-ab265764","title":"Abcam, ab265764, Human SDHAF2 (C11orf79) knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nSDHAF2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 1 and 2 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 1 and 2 bp deletion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-SDHAF2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC11orf79 also known as HAPSTR1 is a protein coding gene. It has a molecular mass of approximately 19 kDa. Researchers have detected its expression in various tissues including the bone marrow spleen and thymus suggesting its physiological role in immune-related contexts. C11orf79 acts mechanistically in cellular contexts where it may influence protein synthesis or transport although detailed mechanical functions remain under investigation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC11orf79 impacts cellular processes in the immune system and has links to the HAPSTR complex where it interacts with other proteins to regulate hematopoiesis. The protein contributes to maintaining normal cell function by aiding in the regulation of proliferation and differentiation of myeloid and lymphoid cells. This suggests its involvement in general immune response and hematopoietic homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nC11orf79 participates in pathways related to immune cell development and function. Notably it engages in the Notch signaling pathway which influences hematopoietic cell differentiation and lymphocyte development. Additionally it interacts with proteins such as NOTCH1 and RBPJ which are essential in both the regulation of developmental processes and maintaining cellular identity.\u003cbr\u003e\nC11orf79 has associations with immune-related diseases like autoimmune lymphoproliferative syndrome (ALPS) and certain leukemias. Its dysfunction may disrupt normal immune cell regulation exacerbating these conditions. Additionally this gene has interactions with proteins like FAS and BAG5 which can influence cell apoptosis and survival suggesting a role in disease pathogenesis where apoptotic pathways become impaired.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845146267817,"sku":"ab265764","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265764","provider":"Iright","version":"1.0","type":"link"}