{"product_id":"abcam-ab265765","title":"Abcam, ab265765, Human ZNF326 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nZNF326 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 1 and 2 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 1 and 2 bp deletion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ZNF326, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZNF326 also known as Znf20 or Zinc Finger Protein 326 functions as a transcriptional regulator influencing gene expression by binding to DNA. It is part of the Krüppel-associated box (KRAB) zinc finger protein family and has a molecular mass of approximately 49 kDa. ZNF326 is expressed in multiple tissues including brain heart and pancreas indicating its broad role in cellular activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein modulates RNA processing and transcriptional regulation often working as part of a transcriptional complex. It interacts with other molecules to facilitate the splicing and processing of pre-mRNA impacting the stability and translation of messenger RNA. This role in RNA biology highlights its importance in maintaining proper cellular function and gene expression profiles.\u003cbr\u003e\nPathways\u003cbr\u003e\nStudies show that ZNF326 participates in the RNA splicing and transcription regulation pathways affecting the expression and function of various genes. It is notably connected with the spliceosome pathway which is important for accurate RNA processing. ZNF326's function alongside proteins like the ATP-dependent RNA helicase DDX5 and serine\/arginine-rich splicing factor 1 (SRSF1) ensures proper assembly and function of spliceosomal components.\u003cbr\u003e\nResearch has linked ZNF326 to neurodegenerative disorders and certain cancers such as glioblastoma. Abnormal activity or expression of ZNF326 disrupts mRNA metabolism contributing to the pathogenesis of these diseases. In glioblastoma ZNF326 works alongside proteins like p53 to influence cellular proliferation and apoptosis thereby playing a role in tumor development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845164945577,"sku":"ab265765","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab265765","provider":"Iright","version":"1.0","type":"link"}