{"product_id":"abcam-ab266097","title":"Abcam, ab266097, Human MKNK2 (MNK2) knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nMKNK2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 20 bp deletion in exon 2 and 4 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 20 bp deletion in exon 2 and 4 bp deletion in exon 2\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-MKNK2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MNK2 kinase also known as MAP kinase-interacting serine\/threonine-protein kinase 2 is a protein that plays a critical role in regulating mRNA translation. It weighs approximately 51 kDa and is part of the larger mitogen-activated protein kinase (MAPK) family. This protein is expressed widely across various tissues including the brain and liver. Its primary function is to phosphorylate specific substrates involved in the process of gene expression control.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMNK2 modulates stress responses by influencing protein synthesis. It is an integral component of the mRNA translation machinery. MNK2 phosphorylates the eukaryotic translation initiation factor 4E (eIF4E) a process that is fundamental for the translation of specific mRNAs. By regulating eIF4E activity MNK2 helps to control the translation of mRNAs involved in stress response and cellular growth.\u003cbr\u003e\nPathways\u003cbr\u003e\nMNK2 is significantly involved in the MAPK signaling pathway and plays a role in the response to cellular stress and growth signals. This pathway includes MAP kinases like ERK which activate MNK2. Through its interaction with eIF4E MNK2 facilitates the synthesis of proteins that are important for cell survival and proliferation in response to extracellular signals. Its action links upstream signaling events influenced by MAP kinases to downstream processes affecting cell growth and stress response.\u003cbr\u003e\nMNK2 has been implicated in cancer due to its role in the regulation of protein synthesis that supports cell proliferation. Abnormal MNK2 activity is linked to tumorigenesis particularly in cancers where eIF4E plays a role like breast and prostate cancer. Moreover its interaction with proteins such as eIF4E and MAP kinases highlights potential targets for therapeutic intervention. By modulating MNK2 activity researchers aim to control aberrant protein synthesis pathways driving these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845150986409,"sku":"ab266097","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab266097","provider":"Iright","version":"1.0","type":"link"}