{"product_id":"abcam-ab267075","title":"Abcam, ab267075, Human ETV7 knockout A549 cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nETV7 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 13 bp deletion in exon 5 and 19 bp deletion in exon 5. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:A549,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Lung,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 13 bp deletion in exon 5 and 19 bp deletion in exon 5,\u003cbr\u003e\nDisease:Carcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ETV7, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ETV7 also known as TEL2 is a member of the ETS family of transcription factors with a molecular weight of approximately 53 kDa. This protein localizes predominantly in the nucleus and influences gene expression regulation. ETV7 is expressed in a variety of tissues with notable expression levels in hematopoietic cells. Its role extends to modulating different genes critical for cellular proliferation and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nETV7 acts as a transcriptional repressor and influences immune responses and cell cycle regulation. This protein functions as part of larger transcriptional complexes interacting with other cofactors to modulate gene expression. ETV7 influences hematopoiesis impacting both the development and function of blood cells by repressing certain cytokine receptors and transcription factors tightly controlling the cellular environment.\u003cbr\u003e\nPathways\u003cbr\u003e\nETV7 plays an integral role in pathways related to hematopoiesis and immune cell regulation. It participates in the JAK-STAT signaling pathway collaborating with proteins such as STAT5 to regulate immune responses and cell proliferation. Additionally ETV7 is involved in the regulation of cytokine signaling pathways impacting cellular growth and immune system balance.\u003cbr\u003e\nETV7 holds significance in the development of certain cancers particularly hematological malignancies. It has associations with acute myeloid leukemia (AML) where its overexpression contributes to leukemogenesis alongside proteins like FLT3. ETV7 also plays a role in B-cell chronic lymphocytic leukemia (CLL) affecting the balance of pro-survival and apoptotic mechanisms further linking its activity with the tumor suppressor protein TP53. Understanding ETV7's interactions helps to illuminate its potential as a therapeutic target in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845135421609,"sku":"ab267075","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab267075","provider":"Iright","version":"1.0","type":"link"}