{"product_id":"abcam-ab267256","title":"Abcam, ab267256, Human SLC41A3 knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nSLC41A3 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 2\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-SLC41A3, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLC41A3 also known as solute carrier family 41 member 3 functions as a magnesium transporter. This protein is part of the broader SLC41 family known for their role in magnesium homeostasis. SLC41A3 has a molecular mass of approximately 56 kDa. It is expressed in various human tissues with notable presence in the heart and skeletal muscle indicating its potential role in these areas.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLC41A3 participates in maintaining the cellular magnesium balance essential for many cellular processes such as enzyme activation and ion channel regulation. The protein acts individually; however it may interact with other magnesium transport proteins to achieve this balance. The maintenance of magnesium levels is necessary for proper cellular function and biochemical reactions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe SLC41A3 protein integrates into the magnesium homeostasis pathway which involves other proteins such as TRPM7 and CNNM2. Within these pathways SLC41A3 contributes to essential physiological processes including muscle contraction and neural activity. Its function is implicit in transport and regulation mechanisms that keep magnesium concentrations within healthy ranges.\u003cbr\u003e\nAlterations in SLC41A3 activity can contribute to magnesium deficiency affecting neuromuscular and cardiovascular systems. Dysregulation may also associate with conditions like hypertension reflecting its involvement with disorders influenced by magnesium levels. Research on SLC41A3's interaction with proteins such as TRPM6 offers insight into potential therapeutic targets for managing these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845202399401,"sku":"ab267256","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab267256","provider":"Iright","version":"1.0","type":"link"}