{"product_id":"abcam-ab268827","title":"Abcam, ab268827, Recombinant human OTUB2 protein (Active)","description":"\u003cp\u003eSize: 5µg\u003cbr\u003e\nRecombinant human OTUB2 protein (Active) is a Human Full Length protein, in the 1 to 234 aa range, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity was determined to be ≥ 22 nmol\/min\/mg in a DUB assay using recombinant human ubiquitin-based proluciferin substrate.,\u003cbr\u003e\nAccession:Q96DC9,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOTUB2 also known as OTU domain-containing ubiquitin aldehyde-binding protein 2 is an enzyme that acts mechanically as a deubiquitinating enzyme. It has a molecular mass of approximately 31 kDa. OTUB2 regulates ubiquitin signaling by cleaving ubiquitin from ubiquitinated proteins. This protein is expressed in various tissues with high expression in the liver and heart. It plays a role in modulating protein degradation and cellular signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein influences cellular processes by interacting with ubiquitin-conjugating enzymes. OTUB2 often joins complexes that include ubiquitin-proteasome machinery components. Through these interactions it controls protein stability and degradation impacting cell cycle progression and DNA damage response. OTUB2's activity is essential for maintaining protein homeostasis which affects how cells respond to stress and changes in their environment.\u003cbr\u003e\nPathways\u003cbr\u003e\nOTUB2 plays roles in the ubiquitin-proteasome and DNA repair pathways. In these pathways its interaction with other proteins like UBC13 and RAD51 is important for its function. These interactions help repair DNA damage and modulate the immune response. By regulating the stability of key signaling proteins OTUB2 ensures proper pathway function and cellular homeostasis.\u003cbr\u003e\nOTUB2 connects to cancer and neurodegenerative diseases. In cancer its regulatory function on protein degradation affects tumor progression and resistance to therapy. With neurodegenerative diseases altered OTUB2 activity can disrupt protein homeostasis leading to accumulation of misfolded proteins. Interactions with proteins such as p53 in cancer and tau in neurodegenerative disorders link OTUB2 to disease mechanisms influencing therapeutic approaches and drug development strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843997749417,"sku":"ab268827","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab268827","provider":"Iright","version":"1.0","type":"link"}