{"product_id":"abcam-ab268955","title":"Abcam, ab268955, Recombinant human SENP8 protein (Active)","description":"\u003cp\u003eSize: 5µg\u003cbr\u003e\nRecombinant human SENP8 protein (Active) is a Human Full Length protein, in the 1 to 212 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity of ab268955 was ≥3434 nmol\/min\/mg in a deubiquitinase assay using recombinant human NEDD8-based proluciferin protein as substrate.,\u003cbr\u003e\nAccession:Q96LD8,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7Preservative: 1.02% ImidazoleConstituents: 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSENP8 also known as SUMO\/Sentrin Specific Peptidase 8 functions as a protein involved in the process of neddylation. SENP8 has a molecular weight of approximately 23 kDa. This protein mediates deneddylation which involves the removal of the small ubiquitin-like protein NEDD8 from its substrates. SENP8 is mainly expressed in tissues where active cell division occurs like spleen thymus and testis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSENP8 plays an important role in regulating neddylation influencing protein stability activity and localization. SENP8 operates independently rather than as a part of any larger protein complex. Its activity is important in cell cycle regulation DNA replication and repair. By removing NEDD8 from target proteins SENP8 controls the degradation of certain proteins impacting cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nSENP8 links tightly with the neddylation and ubiquitin-proteasome pathways. These pathways govern protein turnover and degradation impacting cell cycle control and apoptosis. SENP8 influences proteins such as cullins which are core components of the SCF ubiquitin ligase complex. This relationship highlights SENP8's critical role in cellular protein homeostasis and regulation through these pathways.\u003cbr\u003e\nDysfunctional SENP8 activity connects to cancer and neurodegenerative diseases. Alterations in SENP8 expression or function can lead to uncontrolled cell growth and proliferation linked to certain cancers. SENP8 also has potential connections to Alzheimer's disease due to its effect on protein stability and degradation involving proteins like cullin-1. Changes in neddylation and proteasome pathways indicate SENP8's influence in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843958755497,"sku":"ab268955","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab268955","provider":"Iright","version":"1.0","type":"link"}