{"product_id":"abcam-ab269858","title":"Abcam, ab269858, Anti-GSDMC antibody [EPR20887-50] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal GSDMC antibody. Carrier free. Suitable for WB and reacts with Transfected cell lysate - Mouse, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20887-50,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab269858 is the carrier-free version of\u003cbr\u003e\nab225635\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe GSDMC protein also known as Gasdermin C possesses significant mechanical functions in cells. It has a mass around 54 kDa. The GSDMC protein is mainly expressed in epithelial tissues and can localize to the cytoplasm. Gasdermin C has a role in forming pores in the cell membrane which is a critical step during the pyroptotic cell death process. The protein's expression levels and mechanical properties influence its function in cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGSDMC plays a role in the process of regulated cell death known as pyroptosis. This protein is part of the larger gasdermin family which affect the cellular membrane by creating pores. Through this pore formation GSDMC leads to the release of inflammatory cytokines. By modulating membrane integrity it contributes to immune responses and cell signaling which highlights its influence on cell viability and death.\u003cbr\u003e\nPathways\u003cbr\u003e\nStudies show that GSDMC is involved in the inflammasome pathway and the TNF signaling pathway. It interacts with other proteins like caspase-1 which is important for activating pyroptosis and mediating inflammation. This participation in inflammasome activation positions GSDMC as an important regulator in immune response pathways and cellular homeostasis especially under inflammatory conditions.\u003cbr\u003e\nResearchers have connected GSDMC with cancer progression and inflammatory diseases. The protein's aberrant expression is linked to colorectal cancer and Crohn's disease where it may alter cellular dynamics and impact disease pathology. It associates with proteins such as IL-1β in the context of inflammation which can influence the development and severity of these diseases making GSDMC a potential target for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852289364137,"sku":"ab269858","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab269858","provider":"Iright","version":"1.0","type":"link"}