{"product_id":"abcam-ab270660","title":"Abcam, ab270660, Alexa Fluor® 647 Anti-SLAM \/ CD150 antibody [SLAM.4]","description":"\u003cp\u003eSize: 25Test \/ 100Test\u003cbr\u003e\nMouse Monoclonal SLAM \/ CD150 antibody - conjugated to Alexa Fluor® 647. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing SLAMF1 protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:SLAM.4,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nConjugation:Alexa Fluor® 647,\u003cbr\u003e\nExcitation\/Emission:Ex: 650nm, Em: 665nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Cell preparation containing SLAMF1 protein. The exact immunogen used to generate this antibody is proprietary information.Q13291\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAlexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Size-exclusion chromatography, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLAM also known as CD150 is a cell surface glycoprotein with a molecular weight of approximately 70 kDa. It is mainly expressed on immune cells such as T cells B cells dendritic cells and macrophages. SLAM\/CD150 serves as a receptor that plays an important role in cellular communication by transmitting signals across the cell membrane. These signals influence various immune responses and cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLAM\/CD150 acts as a co-stimulatory molecule that augments the activation and proliferation of T and B cells. It participates in forming signaling complexes through interactions with SLAM-associated protein (SAP). As part of these complexes SLAM\/CD150 regulates cytokine production and modulates immune cell interactions and responses. Furthermore SLAM\/CD150 engagement impacts the stability and formation of immunological synapses.\u003cbr\u003e\nPathways\u003cbr\u003e\nSLAM\/CD150 plays a significant role in the immune signaling cascade. It is involved in the SLAM receptor signaling pathway and interacts closely with proteins like SAP and SH2D1A. These interactions enable signal transduction that modulates downstream effects in T and B cell activation within the immune system. SLAM\/CD150's activity affects lymphocyte development and adaptive immune responses.\u003cbr\u003e\nSLAM\/CD150 is connected to autoimmune disorders and infectious diseases. Its altered signaling contributes to disorders such as X-linked lymphoproliferative disease where interactions with the SAP protein are disrupted. Additionally SLAM\/CD150 serves as a receptor for certain viruses including measles virus implicating it in viral pathogenesis and immune evasion mechanisms. Understanding these associations helps elucidate potential therapeutic targets for managing these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848573014185,"sku":"ab270660","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab270660","provider":"Iright","version":"1.0","type":"link"}