{"product_id":"abcam-ab271297","title":"Abcam, ab271297, Anti-LILRB3 antibody [FRAS92B] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRat Recombinant Monoclonal LIRB3 antibody. Carrier free. Suitable for ICC\/IF, Flow Cyt (Intra), IHC-P and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:FRAS92B,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab271297 is the carrier-free version of\u003cbr\u003e\nab271287\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe 'LILRB3' protein also known as Leukocyte Immunoglobulin Like Receptor B3 is an inhibitory receptor that plays a role in immune response regulation. It weighs approximately 60 kDa and expresses mainly on myeloid cells such as monocytes macrophages and dendritic cells. The receptor interacts with MHC class I molecules and helps in maintaining immune system balance by transmitting inhibitory signals to the immune cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe LILRB3 protein participates in downregulating immune cell activation and preventing overactivation that might lead to tissue damage. It belongs to the family of leukocyte immunoglobulin-like receptors. LILRB3 cooperates with other molecules on the cell surface to form a complex that modulates immune response via the transmission of inhibitory signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe LILRB3 protein is involved in the immune checkpoint pathways that regulate immune cell activity and tolerance. It has important connections with the NF-κB pathway influencing the inflammatory response and maturation of dendritic cells. LILRB3's function relates to the PD-1 pathway which is another regulatory mechanism that ensures immune cells do not become overly active.\u003cbr\u003e\nMalfunction or dysregulation of LILRB3 can lead to autoimmune diseases and affect inflammation levels. It is associated with diseases such as rheumatoid arthritis and systemic lupus erythematosus where immune regulation becomes compromised. The interaction of LILRB3 with proteins like human leukocyte antigen (HLA) systems implies a role in autoimmunity making it a target of interest for therapeutic strategies aiming to restore immune balance.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854650134697,"sku":"ab271297","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab271297","provider":"Iright","version":"1.0","type":"link"}