{"product_id":"abcam-ab271345","title":"Abcam, ab271345, Anti-Surfactant Protein B antibody [RM370]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal PSPB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human SFTPB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:RM370,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SFTPB. The exact immunogen used to generate this antibody is proprietary information.P07988,\u003cbr\u003e\nSpecificity:Reacts with human Surfactant Protein B and pro-Surfactant Protein B.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSurfactant Protein B often called \"mature protein B\" or SP-B plays a mechanical role in the lungs by stabilizing the alveoli during respiration. SP-B with a molecular mass of approximately 8 kDa is highly expressed in the epithelial cells of the alveoli in the pulmonary system. It serves as a critical component in the maintenance and function of pulmonary surfactant which reduces surface tension and prevents the collapse of alveoli during exhalation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSurfactant Protein B participates in lipid spreading and film formation at the air-water interface inside the alveoli. It functions as part of a protein-lipid complex mainly interacting with phospholipids to optimize the surface tension-lowering capabilities of the surfactant. This protein is essential for proper lung function from birth facilitating efficient gas exchange and preventing atelectasis or alveolar collapse.\u003cbr\u003e\nPathways\u003cbr\u003e\nSurfactant Protein B is an important player in the pulmonary surfactant metabolism pathway. This pathway involves the synthesis secretion and recycling of surfactant components necessary for lung function. SP-B works alongside other surfactant proteins like Surfactant Protein C (SP-C) and SP-D to ensure the efficiency of surfactant composition and distribution allowing for normal respiratory processes and homeostasis in lung tissue.\u003cbr\u003e\nSurfactant Protein B mutations or deficiencies lead to severe respiratory conditions such as Surfactant Protein B deficiency disorder in infants which can be life-threatening and require immediate clinical intervention. It links to conditions like neonatal respiratory distress syndrome where lack of SP-B disrupts alveolar surface tension balance. SP-B interacts with other surfactant proteins and phospholipids and disturbances in its function can exacerbate or prognosis for such disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850285863081,"sku":"ab271345","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab271345","provider":"Iright","version":"1.0","type":"link"}