{"product_id":"abcam-ab271354","title":"Abcam, ab271354, Anti-SLFN11 antibody [EPR24414-87]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-SLFN11 antibody [EPR24414-87] (ab271354) is a rabbit monoclonal antibody detecting SLFN11 in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, ICC\/IF . Suitable for  Human . - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24414-87,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WB, Flow Cyt (Intra), IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-SLFN11 antibody [EPR24414-87] (ab271354) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human samples.\u003cbr\u003e\nWhat is the molecular weight of SLFN11?\u003cbr\u003e\nAnti-SLFN11 [EPR24414-87] (ab271354) specifically detects a band for SLFN11 (UniProt: Q7Z7L1) at a molecular weight of 103kDa.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR24414-87] also available for your convenience: ab271354, Carrier free -\u003cbr\u003e\nab283232\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLFN11 also known as Schlafen family member 11 is an important protein involved in the regulation of cellular response to DNA damage. With a molecular mass of approximately 104 kDa SLFN11 is extensively expressed in tumor cells and certain normal tissues particularly in the spleen thymus and testis. This protein contributes to the modulation of interferon-mediated immune responses and impacts translational control by tRNA activation playing a role in ribosomal assembly and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLFN11 functions to enhance the sensitivity of cells to DNA-damaging agents including chemotherapeutic drugs. It is important for impairing replication fork stability by inhibiting the expression of trans-translation machinery. SLFN11 serves as an important determinant within the DNA damage response (DDR) network and is known to interact with other DDR proteins emphasizing its impact on genome integrity and cellular survival under stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nSLFN11 plays a notable role within the pathways associated with the DNA damage response and cell cycle regulation. The protein interacts notably with the ATR signaling pathway which is essential for sensing DNA damage. Additionally SLFN11 forms part of a complex interaction with other DNA repair proteins such as BRCA1 influencing the homologous recombination repair pathway contributing to the cellular determination of treatment response.\u003cbr\u003e\nSLFN11 has significant implications in cancer particularly in the context of treatment response to chemotherapy. Cancers with high SLFN11 expression often exhibit increased sensitivity to cisplatin and other DNA-damaging agents pointing to its potential role as a biomarker for therapeutic efficacy. Moreover the protein is implicated in neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) where its regulation could contribute to the pathophysiology. Its relationship with proteins such as p53 further highlights SLFN11's involvement in cancer and neuroprotection pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850394095785,"sku":"ab271354","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab271354","provider":"Iright","version":"1.0","type":"link"}