{"product_id":"abcam-ab271491","title":"Abcam, ab271491, Recombinant mouse DRAK2 protein (Active)","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant mouse DRAK2 protein (Active) is a Mouse Full Length protein, in the 2 to 372 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;75%, suitable for SDS-PAGE, FuncS, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;75% SDS-PAGE,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, WB, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:Specific Activity: 5 pmole\/min\/μgAssay Conditions: Reaction was performed in 50 mM Tris pH 7.4, 5 mM MgCl2, 1 mM DTT, 20 μM ATP, 0.2 mg\/ml MRCL3 Peptide. Reaction was initiated with the addition of Mouse DRAK2 and was incubated at 30°C for 45 min. The luminescence was read with the Kinase Glo Max reagent.,\u003cbr\u003e\nAccession:Q8BG48,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Mouse,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 5% Glycerol (glycerin, glycerine), 1.19% HEPES, 1.13% Potassium chloride, 0.13% Magnesium chloride, 0.03% Glutathione, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.001% Polyoxyethylene lauryl ether\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDRAK2 also known as Death-associated protein kinase-related apoptosis-inducing protein kinase 2 is part of the serine\/threonine kinase family. This protein has a molecular weight of about 48 kDa. DRAK2 expresses mostly in lymphoid tissues including the spleen and thymus. It plays a role in negative regulation during T-cell receptor signaling and is important during lymphocyte activation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of DRAK2 extends beyond kinase activity. It is involved in immune response modulation and can affect apoptosis in T lymphocytes. DRAK2 is not part of a larger protein complex but rather acts independently to exert its function. It influences cellular mechanisms by altering signaling pathways that impact cell survival and death.\u003cbr\u003e\nPathways\u003cbr\u003e\nYou find DRAK2 involved in both the T-cell receptor signaling and apoptosis pathways. It connects to the T-cell receptor pathway due to its regulation of T-cell activation and proliferation. DRAK2 activity can interact with proteins such as calmodulin and Protein Kinase C in these pathways indicating its role in signaling transduction critical for T-cell function.\u003cbr\u003e\nDRAK2 links to autoimmune diseases and cancer. Abnormal DRAK2 expression might contribute to autoimmune conditions like multiple sclerosis by affecting T-cell autoreactivity. Its involvement in cancer emerges through regulation of apoptosis where malfunction may lead to resistance against cell death aiding cancer cell survival. In this context DRAK2 connection with proteins such as caspases plays a role in mediating apoptotic pathways in cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843842363561,"sku":"ab271491","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab271491","provider":"Iright","version":"1.0","type":"link"}