{"product_id":"abcam-ab272079","title":"Abcam, ab272079, Anti-HAUSP \/ USP7 antibody [BLR072G] - BSA free","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal HAUSP \/ USP7 antibody. Suitable for IHC-P, IP, WB, ICC\/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human USP7 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:BLR072G,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-P, IP, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human USP7 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q93009\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab272079 is the BSA-free version of\u003cbr\u003e\nab264422\u003cbr\u003e\nThis product is sold under License from Bethyl Laboratories, Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 8.2Preservative: 0.09% Sodium azideConstituents: 99% Borate buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHAUSP also known as USP7 is a deubiquitinating enzyme with a molecular mass of approximately 135 kDa. It functions by removing ubiquitin molecules from target proteins influencing their stability and activity. HAUSP is widely expressed in various human tissues with notable presence in the nucleus and cytoplasm. Its expression is essential for modulation of multiple signaling pathways. The enzyme's capacity to regulate protein ubiquitination dynamics makes it a significant player in cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHAUSP influences several critical cellular processes including DNA repair transcriptional regulation and cell cycle progression. It often interacts with other proteins such as p53 to modify their functions by altering their ubiquitination status. HAUSP does not function in isolation but forms part of larger protein complexes where it plays a role in processing substrate proteins. Its ability to activate or deactivate proteins through deubiquitination highlights its importance in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearch identifies HAUSP as an important component in both the p53 pathway and the Wnt signaling pathway. Through the p53 pathway HAUSP directly interacts with the p53 tumor suppressor protein influencing cell cycle and apoptosis decisions. Its participation in the Wnt signaling pathway associates it with beta-catenin where it supports cellular proliferation and differentiation. These pathway interactions illustrate HAUSP's integral role in maintaining cellular function and responding to various signaling inputs.\u003cbr\u003e\nHAUSP has implications in cancer and neurodegenerative diseases. Aberrant activity or expression of HAUSP has been linked to tumorigenesis particularly through its interaction with the proteins p53 and MDM2 affecting cell survival and proliferation. In neurodegenerative conditions altered HAUSP activity may impact protein homeostasis and degradation pathways contributing to disease progression. Its connection to these proteins and disease states highlights its potential as a therapeutic target in associated disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850313027753,"sku":"ab272079","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab272079","provider":"Iright","version":"1.0","type":"link"}