{"product_id":"abcam-ab272461","title":"Abcam, ab272461, Anti-Tetraspanin-33 antibody [EPR23121-146] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Tetraspanin-33 antibody. Carrier free. Suitable for Flow Cyt, Dot and reacts with Human, Recombinant fragment - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23121-146,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Dot, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab272461 is the carrier-free version of\u003cbr\u003e\nab238140\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTetraspanin-33 also known as TSPAN33 or TSPN33 is a protein belonging to the tetraspanin family. It plays a role in organizing other proteins into functional complexes on the cell surface. Tetraspanin-33 weighs approximately 34 kDa and is mainly expressed in hematopoietic tissues which include the bone marrow and lymphoid organs. It is a transmembrane protein with four domains that spans the lipid bilayer influencing cell signaling by clustering with integrins and other membrane proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe organization of proteins into complexes forms an important function of Tetraspanin-33 in the immune system. It regulates cell adhesion migration and signaling impacting various types of immune responses. Tetraspanin-33 interacts with integrins forming tetraspanin-enriched microdomains. Such interactions stabilize the functional arrangements of signaling molecules ensuring precise communication and activation in immune cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nTetraspanin-33 has influential roles in integrin-mediated signaling and immune response pathways. It modulates beta-1 integrin activity and works alongside proteins such as CD9 and CD81 which are also tetraspanins involved in the orchestration of cell adhesion and motility. The signaling modulated by Tetraspanin-33 plays key roles in mediating the cell-cell interactions needed for effective immune function providing a scaffold necessary for the activation and regulation of signaling cascades.\u003cbr\u003e\nDysfunctions involving Tetraspanin-33 appear in immune system disorders and certain types of cancer. Aberrant expression or mutations can relate to conditions such as leukemia where Tetraspanin-33 interacts with proteins like CD53 another tetraspanin involved in immune cell signaling. Additionally alterations in Tetraspanin-33 function might contribute to autoimmune disorders highlighting its importance in maintaining immune system balance and responding to pathogens properly.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851588325545,"sku":"ab272461","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab272461","provider":"Iright","version":"1.0","type":"link"}