{"product_id":"abcam-ab272544","title":"Abcam, ab272544, Anti-TRIB2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TRIB2 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIB2 aa 1-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TRIB2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q92519\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRIB2 also known as Tribbles homolog 2 is a protein involved in various cellular processes. With a molecular weight of approximately 39 kDa TRIB2 acts as a pseudokinase meaning it lacks catalytic activity but can influence other kinases' function. Researchers found TRIB2 expression in several tissues including the liver lung and immune cells. This protein plays a role in regulating cell proliferation differentiation and apoptosis through its interactions with various signaling pathways and molecules.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRIB2 influences cell survival and immune responses. It does not operate alone but forms a part of larger protein complexes to exert its effects. By interacting with transcription factors and other signaling molecules TRIB2 modulates gene expression affecting cell destiny. Though it lacks inherent enzymatic activity TRIB2 can serve as a scaffold or adaptor anchoring other molecules together which significantly shapes cellular dynamics.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRIB2 interacts with several key signaling systems that regulate cell behavior. One notable pathway is the MAPK (Mitogen-Activated Protein Kinase) pathway where TRIB2 affects downstream signaling events that are important for cell growth and response to stress. Additionally TRIB2 engages with the PI3K\/AKT pathway a critical mediator of cell survival and metabolism. Within these pathways TRIB2 aligns with or modulates proteins such as AKT and ERK further integrating its role in cellular communication networks.\u003cbr\u003e\nResearchers have linked TRIB2 to cancer and autoimmune conditions. In the context of cancer elevated TRIB2 levels have been observed in certain leukemias and melanoma where it might promote oncogenic pathways via proteins like C\/EBPα or NF-κB. In autoimmune disorders aberrant TRIB2 expression can disrupt immune cell function potentially enhancing inflammatory processes. The protein may indirectly cause shifts in immune tolerance suggesting its involvement in diseases such as rheumatoid arthritis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854217302185,"sku":"ab272544","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab272544","provider":"Iright","version":"1.0","type":"link"}