{"product_id":"abcam-ab273387","title":"Abcam, ab273387, Tosedostat (CHR2797)","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 406.5 Da, Purity \u0026gt;98%. Aminopeptidase inhibitor (IC50 values are 100, 150, 220, \u0026gt; 1000, \u0026gt; 5000, \u0026gt; 10000 and \u0026gt; 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively). Potently inhibits myeloma cells proliferation and induces tumor growth apoptosis. Effect in cell resistance to conventional chemotherapeutics.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:238750-77-1,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:406.5 Da,\u003cbr\u003e\nMolecular formula:C21H30N2O6,\u003cbr\u003e\nPubChem:15547703,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 50 mM,\u003cbr\u003e\nBiochemical name:Tosedostat,\u003cbr\u003e\nBiological description:Aminopeptidase inhibitor (IC50 values are 100, 150, 220, \u0026gt; 1000, \u0026gt; 5000, \u0026gt; 10000 and \u0026gt; 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively). Potently inhibits myeloma cells proliferation and induces tumor growth apoptosis. Effect in cell resistance to conventional chemotherapeutics.,\u003cbr\u003e\nCanonical smiles:CC(C)CC(C(C(=O)NO)O)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2,\u003cbr\u003e\nIsomeric smiles:CC(C)C[C@H]([C@@H](C(=O)NO)O)C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC2CCCC2,\u003cbr\u003e\nInChi:InChI=1S\/C21H30N2O6\/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-3-5-9-14)21(27)29-15-10-6-7-11-15\/h3-5,8-9,13,15-18,24,28H,6-7,10-12H2,1-2H3,(H,22,25)(H,23,26)\/t16-,17+,18+\/m1\/s1,\u003cbr\u003e\nInChiKey:FWFGIHPGRQZWIW-SQNIBIBYSA-N,\u003cbr\u003e\nIUPAC Name:cyclopentyl (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2720 CHR2797. 2720-25 is the same size as the 25 mg size of ab273387.\u003cbr\u003e\nProtect from air.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation|Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD13 also known as aminopeptidase N (ANPEP) is a transmembrane protein with a molecular weight of approximately 150 kDa. It functions as a zinc-dependent metalloenzyme which cleaves N-terminal amino acids from peptides and proteins. CD13 protein is expressed on various cell types including myeloid cells epithelial cells endothelial cells and fibroblasts. Its presence is significantly observed in the brush border of the small intestinal mucosa and the renal proximal tubule. Researchers can study CD13 using anti-CD13 antibodies and CD13 ELISA kits.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCD13 regulates peptide-mediated signaling and controls the maturation and catabolism of bioactive peptides. The enzymatic function of CD13 influences processes such as cell proliferation motility and angiogenesis. It does not operate as part of a larger complex but its activity modulates several cellular and systemic functions. CD13's role in these biological processes highlights its importance in modulating local and systemic peptide pools which contributes to its diverse physiological effects.\u003cbr\u003e\nPathways\u003cbr\u003e\nCD13 plays significant roles in the renin-angiotensin system and the regulation of inflammatory responses. In the renin-angiotensin system CD13 modulates the activity of angiotensin influencing blood pressure and fluid balance. Through its enzymatic activity CD13 interacts with proteins such as ACE another critical player in this pathway. In inflammation CD13 regulates the availability of chemotactic peptides affecting leukocyte migration and adhesion. The proteins it works with in inflammatory pathways include cytokines which CD13 indirectly modulates by altering chemokine activity.\u003cbr\u003e\nAberrant CD13 expression and activity are implicated in cancer and inflammatory diseases. In cancer overexpression of CD13 correlates with tumor growth and metastasis particularly in cancers like renal cell carcinoma and prostate cancer. It can confer an increased malignant phenotype by promoting angiogenesis and immune evasion. In inflammatory disorders dysregulation of CD13 exacerbates diseases such as rheumatoid arthritis through its impact on peptide-mediated signaling and immune cell movement. Its connection with inflammatory cytokines like IL-8 indicates its important role in mediating inflammatory responses.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847473615017,"sku":"ab273387","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab273387","provider":"Iright","version":"1.0","type":"link"}