{"product_id":"abcam-ab273511","title":"Abcam, ab273511, Anti-Androgen Receptor (AR-V7 specific) antibody [EPR15656-290] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Androgen Receptor antibody. Carrier free. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15656-290,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab273511 is the carrier-free version of\u003cbr\u003e\nab273500\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Androgen Receptor (AR-V7 specific) is a variant of the androgen receptor a type of nuclear receptor critical for mediating the effects of androgens like testosterone. AR-V7 is a protein that lacks the ligand-binding domain present in full-length androgen receptors resulting in its activity being independent of androgen presence. It is prominently expressed in prostate tissues and is often observed in prostate cancer cells resistant to conventional therapies. The protein variant exhibits a molecular mass of about 75 kDa. Commonly recognized aliases for AR-V7 include AR-V7 ARv7 and AR V7.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe AR-V7 is significant in cellular proliferation and survival processes without needing direct androgen binding due to its interaction capability with specific nuclear elements. It resides in the cell nucleus and engages with DNA as part of a transcriptional regulatory complex. Its ability to modulate the transcription of target genes makes it a prominent player in the regulation of cell cycle and apoptosis. In many instances AR-V7 forms complexes with other transcriptional modulators and nuclear proteins that augment its transcriptional activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nAR-V7 plays an important role in the androgen signaling pathway which is pivotal in the progression and development of prostate cancer. It interacts with various co-regulators and influences the expression of genes involved in cell growth and differentiation. The splice variant also participates in other related signaling pathways such as the PI3K\/AKT pathway indirectly interfacing with proteins like AR peptides and AR protein which further highlights its relevance in intracellular signaling mechanisms.\u003cbr\u003e\nAR-V7 has a well-established connection with castration-resistant prostate cancer (CRPC) a form of prostate cancer that progresses despite androgen deprivation therapy. The presence of AR-V7 signifies a poor prognosis and resistance to anti-androgen therapies. Its transcriptional activity is linked to proteins such as AR protein and anti-androgen agents that typically target the full-length androgen receptor. Understanding the role of AR-V7 in reinforcing cancer cell survival and therapy resistance has fueled research towards developing targeted therapeutics and diagnostics like AR-V7 ELISA kits and AR IHC assays.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851845521577,"sku":"ab273511","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab273511","provider":"Iright","version":"1.0","type":"link"}