{"product_id":"abcam-ab273599","title":"Abcam, ab273599, BIIB 021","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 318.76 Da, Purity \u0026gt;98%. Selective, Hsp90 competitive inhibitor (K i  = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na + K +  ATPase. Induces degradation of HER-2  in vitro  (EC 50  = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:848695-25-0,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:318.76 Da,\u003cbr\u003e\nMolecular formula:C14H15ClN6O,\u003cbr\u003e\nPubChem:16736529,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine,\u003cbr\u003e\nBiological description:Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.,\u003cbr\u003e\nCanonical smiles:CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N,\u003cbr\u003e\nInChi:InChI=1S\/C14H15ClN6O\/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21\/h4,6H,5H2,1-3H3,(H2,16,19,20),\u003cbr\u003e\nInChiKey:QULDDKSCVCJTPV-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847464243369,"sku":"ab273599","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab273599","provider":"Iright","version":"1.0","type":"link"}