{"product_id":"abcam-ab275934","title":"Abcam, ab275934, Anti-PTPRH antibody [EPR20897-15] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal PTPRH antibody. Carrier free. Suitable for ICC\/IF, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20897-15,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab275934 is the carrier-free version of\u003cbr\u003e\nab231767\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPTPRH also known as human protein tyrosine phosphatase receptor type H (SAP-1) is a receptor-type protein tyrosine phosphatase. It weighs around 130 kDa. This protein is mainly found in epithelial tissues including the liver pancreas stomach and intestines. PTPRH contains an extracellular domain a single transmembrane region and an intracellular catalytic domain playing a significant role in dephosphorylation processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPTPRH functions as a regulator of cellular signaling processes by modulating phosphorylation levels. It acts in the cellular communication network impacting cell growth differentiation and adhesion. This protein does not usually exist as part of a larger complex but interacts directly with phosphorylated substrates to exert its activity. PTPRH’s role in modulating signal transduction affects various cellular processes from metabolism to immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nPTPRH shows involvement in the MAPK\/ERK signaling pathway and the PI3K\/AKT signaling pathway. These pathways are important for transmitting extracellular signals to regulate gene expression and cell survival. PTPRH impacts molecular partners such as ERK and AKT through dephosphorylation influencing cellular responses. Its activity also integrates with other signaling molecules ensuring accurate control over cellular functions.\u003cbr\u003e\nPTPRH associates with several pathologies with notable implications in cancer and liver disease. Loss of PTPRH function or alterations in its expression levels have been linked to colorectal cancer development due to disrupted cellular signaling. Additionally changes in PTPRH activity can affect proteins like EGFR which plays a part in cell proliferation and survival further connecting it to oncogenic processes. Understanding PTPRH's role provides insights into mechanisms leading to disease progression and potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848544014505,"sku":"ab275934","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab275934","provider":"Iright","version":"1.0","type":"link"}