{"product_id":"abcam-ab276056","title":"Abcam, ab276056, Anti-GBA3 antibody [008] - BSA and Azide free","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal GBA3 antibody. Carrier free. Suitable for ICC, Flow Cyt (Intra) and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GBA3 aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:008,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GBA3 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H227\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGBA3 also known as cytosolic beta-glucosidase is an enzyme with a molecular mass of approximately 60 kDa. This protein functions to hydrolyze glycosides specifically beta-D-glucosides and other saccharide derivatives facilitating the breakdown of these molecules into useful substrates for the cell. GBA3 is expressed in various tissues such as liver kidney and small intestine indicating its widespread role in metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEnzymes like cytosolic beta-glucosidase contribute to essential digestive and metabolic processes by breaking down glycosidic bonds found in complex carbohydrates. They are not part of a larger protein complex but they cooperate with other enzymes to maintain energy production from dietary sources. This activity helps the organism to manage carbohydrate metabolism effectively releasing simple sugars that cells use for energy.\u003cbr\u003e\nPathways\u003cbr\u003e\nGBA3 interacts closely with glycolysis and gluconeogenesis important pathways for energy homeostasis. In these pathways GBA3's role in carbohydrate breakdown supplies simple sugars that enter further stages of energy production. It acts alongside proteins like glucokinase and phosphoglucomutase which also contribute to these metabolic pathways aiding in the management of energy resources in the body.\u003cbr\u003e\nAbnormal activity or expression of GBA3 can link to metabolic conditions like Gaucher's disease and Niemann-Pick disease. These are lysosomal storage disorders where disruptions in glycoside processing can lead to harmful accumulation of glucosylceramides. Proteins such as glucocerebrosidase (GBA1) are also affected in these disorders highlighting a network where GBA3 activity is vital for preventing substrate buildup and maintaining cellular health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850482634921,"sku":"ab276056","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab276056","provider":"Iright","version":"1.0","type":"link"}