{"product_id":"abcam-ab277525","title":"Abcam, ab277525, Anti-Neurocan antibody [EPR23425-68]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Neurocan antibody. Suitable for ICC\/IF, WB, IHC-P and reacts with Mouse, Human, Rat samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23425-68,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeurocan also known as CSPG3 is a chondroitin sulfate proteoglycan with a core protein mass around 245 kDa. It is expressed mostly in the central nervous system. Neurocan plays a mechanical role in modulation of cell adhesion and migration interacting with other extracellular matrix components like tenascin-C and hyaluronic acid. This interaction helps regulate how neurons and glial cells move and connect during development and after injury.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeurocan functions significantly in the neural extracellular matrix influencing neural plasticity and maintaining brain homeostasis. It is often found as part of a proteoglycan complex interacting with other matrix molecules. Its molecular structure allows it to bind and influence growth factors impacting neurogenesis and synaptic maintenance. The presence of neurocan is especially significant during periods of neural development and remodeling serving as a regulatory element in these processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeurocan plays a part in the regulation of nervous system development and neural repair mechanisms. The protein actively participates in the MAPK signaling pathway affecting cellular responses like proliferation and differentiation. Neurocan relates to proteins like fibronectin and integrins within these pathways contributing to structure and signaling that affect cellular environments and neuron network formations.\u003cbr\u003e\nNeurocan holds associations with conditions like schizophrenia and neurotrauma. Altered expression or mutations within the neurocan gene can contribute to the disrupted neural connectivity seen in schizophrenia. Furthermore neurocan interacts with proteins such as aggrecan and versican in response to neural injuries forming glial scars that can inhibit proper neural repair and recovery processes. Understanding the role of neurocan in these diseases is essential in developing therapeutic strategies targeting neural plasticity and repair mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850287435945,"sku":"ab277525","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab277525","provider":"Iright","version":"1.0","type":"link"}