{"product_id":"abcam-ab278049","title":"Abcam, ab278049, Anti-Complement factor 8 beta\/C8B antibody [EPR23764-1] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CO8B antibody. Carrier free. Suitable for IP, WB, IHC-P and reacts with Human, Recombinant full length protein - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23764-1,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab278049 is the carrier-free version of\u003cbr\u003e\nab278045\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nComplement factor 8 beta (C8B) is an essential protein component of the complement system an important part of the immune response. Commonly referred to as C8B this protein has a molecular mass of approximately 64 kilodaltons. C8B is primarily expressed in liver tissue where it contributes to the formation of the C8 protein complex a component necessary for the assembly of the membrane attack complex (MAC). Other names for this target include complement component C8 beta chain emphasizing its role in the complement cascade.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe C8B protein facilitates the stabilization of the C8 complex which also consists of the alpha and gamma chains to perform its role in the immune system. It plays an important role in forming the MAC an important structure for lysing pathogenic cells like bacteria by disrupting their plasma membranes. This action highlights the importance of C8B in innate immunity where it enables the host to eliminate harmful cells effectively.\u003cbr\u003e\nPathways\u003cbr\u003e\nC8B's activities are integral to the complement cascade specifically within the terminal membrane attack pathway. It functions in conjunction with other complement factors like complement factor 5 to 9 forming a cascade of sequential activations. C8B works closely with complement factor 8 alpha and complement factor C5 within this pathway to achieve effective immune responses. These interactions ensure the proper function of the immune surveillance mechanism allowing the organism to protect itself against microbial infections.\u003cbr\u003e\nC8B has significant connections to immunodeficiencies and inflammatory conditions. Patients with deficiencies in any of the components forming the MAC including C8B often suffer from recurrent Neisserial infections due to impaired bacterial lysis. C8B mutations contribute to properdin-independent pathway issues that can lead to susceptibility to such infections. Moreover malfunction in C8B can associate with autoimmune disorders implying a disruption in the delicate balance of the immune response where proteins like factor 8 and complement factor 5 play critical roles in maintaining immunity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851749150889,"sku":"ab278049","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab278049","provider":"Iright","version":"1.0","type":"link"}