{"product_id":"abcam-ab278529","title":"Abcam, ab278529, Anti-Bcl3 antibody [EPR23835-115] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal BCL3 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23835-115,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab278529 is the carrier-free version of\u003cbr\u003e\nab259832\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Bcl3 protein also known as Bcl-3 is a member of the IκB family of proteins. It serves a mechanical role as a transcription coactivator that interacts with NF-κB p50 and p52 homodimers. The Bcl3 protein has a molecular weight of approximately 45 kDa. This protein expresses primarily in lymphoid tissues including spleen and lymph nodes usually found within the nucleus where it performs its function in regulating gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBcl3 interacts with specific components of the NF-κB complex and modulates signaling pathways involved in immune responses inflammation and cell proliferation. Bcl3 helps in the stabilization and activation of p50\/p52 dimers which facilitate the transcription of target genes. Its role necessitates its function within larger complexes that are essential for transcriptional regulation. Bcl3's interaction with other transcription factors allows it to fine-tune the expression of a range of genes impacting several cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nBcl3 plays a significant role in the regulation of the NF-κB signaling pathway. It acts by modulating the activity of NF-κB dimers important for immune response and inflammation. Furthermore it affects the PI3K\/Akt pathway by influencing the expression of genes that are relevant to cell survival and apoptosis. Proteins such as p50 and p52 in the NF-κB pathway closely relate to Bcl3 function highlighting its role in cellular signaling networks.\u003cbr\u003e\nBcl3 is linked to certain types of cancers and autoimmune diseases. Its abnormal expression associates with disorders like chronic lymphocytic leukemia where it may contribute to disease progression by affecting cell proliferation and survival. Bcl3's interaction with NF-κB components can also influence rheumatoid arthritis where it might play a part in exacerbating inflammation. Proteins such as p50 and other NF-κB pathway components connect Bcl3 to these diseases reflecting its importance in disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851210150057,"sku":"ab278529","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab278529","provider":"Iright","version":"1.0","type":"link"}