{"product_id":"abcam-ab279340","title":"Abcam, ab279340, Anti-IFFO2 antibody [EPR22712-35] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal IFFO2 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Rat, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22712-35,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab279340 is the carrier-free version of\u003cbr\u003e\nab242131\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIFFO2 also known as Interferon-Induced Protein with Tetratricopeptide Repeats 2 is a protein that typically weighs approximately 110 kDa. It localizes mainly in the cytoplasm and nucleus expressing in various tissues with higher presence in immune tissues and the brain. This protein participates in cellular signaling processes by interacting with other molecular complexes and proteins through its tetratricopeptide repeat domains. The role of IFFO2 in these regions suggests a part in coordinating cellular responses to external stimuli.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIFFO2 contributes to immune modulation and cellular stress response. It associates with larger protein complexes aiding in the regulation of gene expression and protein stability. IFFO2 influences how cells react to viral infections through its interactions adapting cellular processes to enhance responsiveness to interferons. This dimension of functionality underlines its involvement in defensive mechanisms against pathogens showcasing its significance in immune regulation networks.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein interacts within the interferon signaling pathway and plays a part in the regulation of apoptosis. IFFO2 relates to interferon regulatory factor 3 (IRF3) aiding in the enhancement of antiviral defenses. Additionally it may affect the expression of other important signaling molecules such as NF-kB showing its coordination role in controlling cell fate decisions. Its involvement in these pathways places it among the core regulators of immune and stress-response dynamics.\u003cbr\u003e\nIFFO2 relates to neurodegenerative disorders and cancer. Its interaction with p53 protein points to its role in tumor suppression as it influences cell cycle arrest and apoptosis. Alterations in IFFO2 might contribute to pathological developments like Alzheimer's disease where disrupted immune function and protein aggregation are notable. Understanding IFFO2's regulatory impact could provide new insights into therapeutic strategies against these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851753672873,"sku":"ab279340","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab279340","provider":"Iright","version":"1.0","type":"link"}