{"product_id":"abcam-ab281838","title":"Abcam, ab281838, Anti-TM9SF2 antibody [EPR24416-17] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TM9SF2 antibody. Carrier free. Suitable for WB, IHC-Fr, Flow Cyt (Intra), IHC-P and reacts with Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24416-17,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WB, Flow Cyt (Intra), IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab281838 is the carrier-free version of\u003cbr\u003e\nab271123\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTM9SF2 also known as Transmembrane 9 Superfamily Member 2 is a membrane protein with a mass of approximately 80 kDa. It functions as a transmembrane transporter that may influence ion homeostasis. TM9SF2 is mainly expressed in the endoplasmic reticulum and Golgi apparatus of cells where it likely impacts protein processing and trafficking. Due to its nature as a membrane protein TM9SF2 may also have roles in cellular signaling. Alternate names for TM9SF2 include TMS9 and Nonaspanin.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTM9SF2 influences cellular processes by contributing to membrane integrity and protein sorting. As a possible member of larger protein complexes within the cell TM9SF2 interacts with other transmembrane proteins to facilitate intracellular trafficking pathways. This protein may modify the sorting and secretion of enzymes or hormones through its action on vesicular transport mechanisms therefore affecting various metabolic and signaling processes within the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nTM9SF2 is involved in membrane trafficking and protein secretion important for maintaining cellular homeostasis. It associates with important biological pathways such as vesicular transport pathways and intracellular sorting pathways. TM9SF2 acts together with proteins like SNAREs and Rab GTPases contributing to vesicle budding fusion and transport. This association helps coordinate how proteins are delivered to different cellular destinations integrating TM9SF2's function within the broader picture of cellular operations.\u003cbr\u003e\nTM9SF2 has connections with metabolic diseases and neurological disorders. Alterations in TM9SF2 expression have been linked with abnormal lipid metabolism and could play a role in the pathogenesis of obesity and type 2 diabetes. Additionally irregularities in its function might influence neurodegenerative conditions by affecting protein trafficking and degradation pathways. TM9SF2 interacts with proteins such as APP (Amyloid precursor protein) suggesting potential involvement in Alzheimer's disease where protein misprocessing leads to amyloid plaque formation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851625910441,"sku":"ab281838","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab281838","provider":"Iright","version":"1.0","type":"link"}