{"product_id":"abcam-ab281997","title":"Abcam, ab281997, Anti-ARL8A + ARL8B antibody [EPR24376-103]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ARL8A antibody. Suitable for ICC\/IF, WB and reacts with Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24376-103,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nARL8A and ARL8B also known as ADP-ribosylation factor-like protein 8A and 8B are small GTPases with masses of approximately 21 kDa. They belong to the ARF-like GTPase family and they localize mainly on lysosomes and late endosomes. Both ARL8A and ARL8B widely express in tissues but show higher levels in certain types like immune cells. Their structural and functional similarities allow them to share roles in cellular functions related to lysosomal positioning and movement.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nARL8A and ARL8B regulate the anterograde transport of lysosomes and are part of the lysosomal trafficking complex. They help in organizing lysosomal positioning a role important for normal lysosome function. This function includes interaction and formation of a complex with other proteins such as PLEKHM2 and SKIP which facilitate the attachment of lysosomes to microtubule tracks via kinesin motor proteins. This movement allows lysosomes to fulfill their roles in cellular distribution and degradation processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nARL8A and ARL8B play roles in the lysosomal protein transport pathway and autophagy. They engage in lysosomal motility impacting autophagic flux a process essential for cellular homeostasis and stress response. ARL8B in particular interacts with the HOPS complex promoting fusion between autophagosomes and lysosomes therefore influencing autophagy. Among related proteins Rab7A is noteworthy as a regulator of late endosomal trafficking pathways that interface with processes involving ARL8 proteins.\u003cbr\u003e\nARL8A and ARL8B are associated with neurodegenerative diseases and cancer. Dysregulation in lysosomal positioning can impair autophagy linking these proteins to neurodegenerative conditions like Parkinson's disease. In cancer altered lysosomal trafficking influences tumor cell invasion and metastasis. Both proteins interact with LAMP proteins which contribute to the lysosomal membrane integrity central to diseases involving lysosomal dysfunction.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850327904425,"sku":"ab281997","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab281997","provider":"Iright","version":"1.0","type":"link"}