{"product_id":"abcam-ab282420","title":"Abcam, ab282420, THZ1","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 566.1 Da, Purity 97%. A potent (IC 50  = 15.6nM at 20 minutes) and selective inhibitor that combines allosteric covalent binding and ATP-site binding to irreversibly inhibit cyclin-dependent kinase 7 (CDK7). It demonstrates strong anti-proliferative effects across types of cancers and cell lines by disrupting transcription of several proteins and decreasing binding of STAT3 chromatin and target gene expression of genes such as MYC and PIM1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1604810-83-4,\u003cbr\u003e\nPurity:97%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:566.1 Da,\u003cbr\u003e\nMolecular formula:C31H28ClN7O2,\u003cbr\u003e\nPubChem:73602827,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO (up to at least 25 mg\/ml),\u003cbr\u003e\nBiochemical name:Thz1,\u003cbr\u003e\nBiological description:A potent (IC50 = 15.6nM at 20 minutes) and selective inhibitor that combines allosteric covalent binding and ATP-site binding to irreversibly inhibit cyclin-dependent kinase 7 (CDK7). It demonstrates strong anti-proliferative effects across types of cancers and cell lines by disrupting transcription of several proteins and decreasing binding of STAT3 chromatin and target gene expression of genes such as MYC and PIM1.,\u003cbr\u003e\nCanonical smiles:CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl,\u003cbr\u003e\nIsomeric smiles:CN(C)C\/C=C\/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl,\u003cbr\u003e\nInChi:InChI=1S\/C31H28ClN7O2\/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27\/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)\/b11-6+,\u003cbr\u003e\nInChiKey:OBJNFLYHUXWUPF-IZZDOVSWSA-N,\u003cbr\u003e\nIUPAC Name:N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSolutions in DMSO may be stored at -20°C for up to 3 months.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847423905961,"sku":"ab282420","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab282420","provider":"Iright","version":"1.0","type":"link"}