{"product_id":"abcam-ab282821","title":"Abcam, ab282821, Anti-GALR2 antibody [EPR24328A-120] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal GALR2 antibody. Carrier free. Suitable for ICC\/IF, IHC-Fr, IHC-P, mIHC and reacts with Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24328A-120,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat,\u003cbr\u003e\nApplications:IHC-Fr, IHC-P, mIHC, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab282821 is the carrier-free version of\u003cbr\u003e\nab271019\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGALR2 also known as Galanin receptor type 2 is a G protein-coupled receptor with a molecular mass of around 38 kDa. This receptor is expressed in several tissues including the central nervous system peripheral nervous system and various peripheral organs. GALR2 interacts with the neuropeptide galanin which modulates several physiological functions. The receptor signals through different classes of G proteins leading to the activation of intracellular second messengers.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGALR2 influences numerous processes essential for maintaining homeostasis. It mediates cellular responses to stress appetite and mood through interaction with its ligand galanin. Though GALR2 does not form part of a larger receptor complex it plays a central role in its signaling pathways. Researchers recognize its function in promoting neurogenesis and modulating neurotransmitter release impacting several neural circuits.\u003cbr\u003e\nPathways\u003cbr\u003e\nGALR2 plays roles in the MAPK\/ERK pathway and the PI3K\/AKT pathway. These pathways are essential for cell survival differentiation and proliferation. GALR2 interacts closely with other receptors such as GALR1 and GALR3 sharing similar downstream effects while maintaining distinct cellular responses. Such interactions help coordinate various physiological functions like memory and feeding behavior.\u003cbr\u003e\nGALR2 has associations with depression and epilepsy. The receptor's modulation of mood regulation links it to depressive disorders while its influence on neurotransmitter release affects epilepsy-related pathways. In these conditions GALR2 often works with other galanin receptors particularly GALR1 to mechanisms that underpin neural dysfunction and resilience. Understanding its roles provides insight into potential therapeutic targets for managing these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851573612713,"sku":"ab282821","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab282821","provider":"Iright","version":"1.0","type":"link"}