{"product_id":"abcam-ab284839","title":"Abcam, ab284839, Anti-QDPR\/DHPR antibody [EP12595] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Monoclonal QDPR\/DHPR antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP12595,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab284839 is the carrier-free version of\u003cbr\u003e\nab186411\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nQDPR also known as Quinoid Dihydropteridine Reductase or DHPR is an enzyme that plays an important role in tetrahydrobiopterin (BH4) regeneration. It has a molecular mass of approximately 25 kDa and is found in various tissues such as the liver and brain where it contributes to neurotransmitter synthesis and other physiological processes. The DHPR protein is encoded by the QDPR gene in humans and is highly conserved across species indicating its essential function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nQDPR catalyzes the reduction of quinonoid dihydrobiopterin (qBH2) to tetrahydrobiopterin maintaining BH4 homeostasis. This process supports neurotransmitter synthesis by replenishing BH4 a cofactor for aromatic amino acid hydroxylases. QDPR does not operate as part of a large multi-protein complex but has a significant role as a standalone enzyme that assists hydroxylating enzymes important for dopamine serotonin and nitric oxide production.\u003cbr\u003e\nPathways\u003cbr\u003e\nQDPR contributes to the biosynthesis of catecholamines and serotonin both essential neurotransmitter pathways. It supports phenylalanine hydroxylase tyrosine hydroxylase and tryptophan hydroxylase activities by sustaining BH4 levels. These pathways are integral to proper neurological function and are tightly regulated due to their dependence on QDPR's enzymatic activity. The function of QDPR aligns with the regulation of neurotransmitter metabolism working alongside other critical proteins in these pathways.\u003cbr\u003e\nQDPR deficiency can result in hyperphenylalaninemia a condition characterized by elevated phenylalanine levels leading to cognitive impairments. This deficiency affects neurotransmitter synthesis linking it to neurological diseases such as depressive disorders. Additionally QDPR-related disruptions can implicate other proteins like phenylalanine hydroxylase showing how these metabolic pathways and their components are interwoven into broader physiological contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851733422249,"sku":"ab284839","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab284839","provider":"Iright","version":"1.0","type":"link"}