{"product_id":"abcam-ab285394","title":"Abcam, ab285394, Elevenostat","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 315.32 g\/mol, Purity \u0026gt;95%. A small molecule hydroxamic acid derivative that acts as a HDAC11-selective inhibitor. Reporter assays using a luciferase-linked Foxp3 promoter shows that HDAC11 decreases the signal driven by NFκB\/p65, alone or in the presence of transfected Foxp3, and impairs luciferase activity driven by p65, Foxp3 and the HAT enzyme, p300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:315.32 g\/mol,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO,\u003cbr\u003e\nBiological description:A small molecule hydroxamic acid derivative that acts as a HDAC11-selective inhibitor. Reporter assays using a luciferase-linked Foxp3 promoter shows that HDAC11 decreases the signal driven by NFκB\/p65, alone or in the presence of transfected Foxp3, and impairs luciferase activity driven by p65, Foxp3 and the HAT enzyme, p300.The inhibitory effects of HDAC11 at the Foxp3 promoter are reversed by Elevenostat (JB3-22), (IC50 0.235 μM). Elevenostat also partially reverses the inhibitory effect of HDAC11 on p300-induced Foxp3 acetylation at lysine 31 consistent with the ability of HDAC11 to directly regulate acetylation of Foxp3.,\u003cbr\u003e\nCanonical smiles:O=C(NO)C1=CC=C(CNC(NC2=CC=CC=C2OC)=O)C=C1,\u003cbr\u003e\nInChi:InChI=1S\/C16H17N3O4\/c1-23-14-5-3-2-4-13(14)18-16(21)17-10-11-6-8-12(9-7-11)15(20)19-22\/h2-9,22H,10H2,1H3,(H,19,20)(H2,17,18,21),\u003cbr\u003e\nInChiKey:DZHNFBYCLJKJID-UHFFFAOYSA-N\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1893 Elevenostat. B1893-1 is the same size as the 1 mg size of ab285394.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847495995561,"sku":"ab285394","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab285394","provider":"Iright","version":"1.0","type":"link"}