{"product_id":"abcam-ab285427","title":"Abcam, ab285427, Timentin","description":"\u003cp\u003eSize: 1g \/ 25g\u003cbr\u003e\nMW 583.6 Da. Inhibits β-Lactamase. Timentin (Ticarcillin Disodium Salt\/Potassium Clavulanate) is highly effective against gram negative bacteria such as Agrobacterium strains.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:4697-14-7,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:583.6 Da,\u003cbr\u003e\nMolecular formula:C23H25N3O11S2,\u003cbr\u003e\nPubChem:6437075,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:H2O,\u003cbr\u003e\nBiochemical name:Ticarcillin-clavulanic acid,\u003cbr\u003e\nBiological description:Inhibits β-Lactamase. Timentin (Ticarcillin Disodium Salt\/Potassium Clavulanate) is highly effective against gram negative bacteria such as Agrobacterium strains.,\u003cbr\u003e\nCanonical smiles:CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CSC=C3)C(=O)O)C(=O)O)C.C1C2N(C1=O)C(C(=CCO)O2)C(=O)O,\u003cbr\u003e\nIsomeric smiles:CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CSC=C3)C(=O)O)C(=O)O)C.C1[C@@H]2N(C1=O)[C@H](\/C(=C\/CO)\/O2)C(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C15H16N2O6S2.C8H9NO5\/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4\/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);1,6-7,10H,2-3H2,(H,12,13)\/b;4-1-\/t7-,8-,9+,12-;6-,7-\/m11\/s1,\u003cbr\u003e\nInChiKey:XWMVMWTVLSLJGY-FAJPTIRJSA-N,\u003cbr\u003e\nIUPAC Name:(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1508 Timentin. B1508-25g is the same size as the 25 g size of ab285427.\u003cbr\u003e\nDo not take internally. Wear gloves and mask when handling.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate long-term storage conditions-+4°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store under desiccating conditions\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBeta-lactamase is an enzyme responsible for breaking down beta-lactam antibiotics such as penicillins and cephalosporins. This enzyme is also known by several names: beta lactamase beta-lactamase and b-lactamase. It has a molecular weight of approximately 29 kDa. Mainly beta-lactamase is expressed in various bacterial species including Escherichia coli and Staphylococcus aureus where it provides them with resistance against beta-lactam antibiotics. The presence of beta-lactamase significantly impacts the efficacy of these antibiotics in clinical settings.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBeta-lactamase enzymes interact with beta-lactam antibiotics by hydrolyzing the beta-lactam ring within the antibiotic molecule. This action prohibits the antibiotics from binding to their bacterial targets rendering them ineffective. Beta-lactamase does not function alone; it can associate with other proteins in bacteria such as the outer membrane proteins which facilitate its secretion and activity. This enzyme is not part of a larger complex but works independently to confer antibiotic resistance to the host organism.\u003cbr\u003e\nPathways\u003cbr\u003e\nBeta-lactamase plays a critical role in the antibiotic resistance pathway. This enzyme links to the cell wall biosynthesis pathway by inhibiting antibiotics that target bacterial cell wall synthesis. Because of this inhibition the production of cell wall components continues unhindered. Beta-lactamase activity is associated with penicillin-binding proteins (PBPs) which are the intended targets of beta-lactam antibiotics. By preventing the binding of antibiotics to these PBPs beta-lactamase ensures the survival of resistant bacterial strains.\u003cbr\u003e\nBeta-lactamase contributes significantly to antibiotic resistance leading to infections that are difficult to treat such as methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Escherichia coli infections. These bacteria produce beta-lactamase neutralizing the therapeutic effects of many commonly used antibiotics. The enzyme's action connects it to other proteins involved in resistance mechanisms like efflux pumps and proteases which also play parts in shielding bacteria from antibacterial agents. This correlation underlines the necessity for developing inhibitors that target beta-lactamase without hindering beneficial bacterial functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847500583081,"sku":"ab285427","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab285427","provider":"Iright","version":"1.0","type":"link"}