{"product_id":"abcam-ab285439","title":"Abcam, ab285439, TLR2-IN-C29","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 285.29 Da, Purity \u0026gt;98%. Inhibitor of TLR2\/1 and TLR2\/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2\/1 signaling in murine macrophages. It prevents the early activation of TLR2-mediated signaling, including NF-κB and MAPKs, as well as MyD88 recruitment to TLR2 in THP-1 cells.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:363600-92-4,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:285.29 Da,\u003cbr\u003e\nMolecular formula:C16H15NO4,\u003cbr\u003e\nPubChem:3579893,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO,\u003cbr\u003e\nBiochemical name:Tlr2-IN-C29,\u003cbr\u003e\nBiological description:Inhibitor of TLR2\/1 and TLR2\/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2\/1 signaling in murine macrophages. It prevents the early activation of TLR2-mediated signaling, including NF-κB and MAPKs, as well as MyD88 recruitment to TLR2 in THP-1 cells.,\u003cbr\u003e\nCanonical smiles:CC1=C(C=CC=C1N=CC2=C(C(=CC=C2)OC)O)C(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C16H15NO4\/c1-10-12(16(19)20)6-4-7-13(10)17-9-11-5-3-8-14(21-2)15(11)18\/h3-9,18H,1-2H3,(H,19,20),\u003cbr\u003e\nInChiKey:WTGMGRFVBFDHGQ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-[(2-hydroxy-3-methoxyphenyl)methylideneamino]-2-methylbenzoic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2121 TLR2-IN-C29. B2121-5 is the same size as the 5 mg size of ab285439.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847501205673,"sku":"ab285439","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab285439","provider":"Iright","version":"1.0","type":"link"}