{"product_id":"abcam-ab28557","title":"Abcam, ab28557, Anti-ADAMTS7 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ADAMTS7 antibody. Suitable for WB and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 7.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 7. The exact immunogen used to generate this antibody is proprietary information.Q9UKP4,\u003cbr\u003e\nSpecificity:ab28557 recognizes metalloproteinase ADAMTS7.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody has been peptide-affinity purified., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 50% Sucrose, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nADAMTS7 also known as ADAM Metallopeptidase with Thrombospondin Type 1 Motif 7 is an enzyme with a molecular mass of approximately 180 kDa. This protein is part of the ADAMTS family characterized by a disintegrin and metalloproteinase with thrombospondin motifs. ADAMTS7 is expressed mainly in the human kidney liver and skeletal muscle tissues. This protein plays a significant role in the degradation and remodeling of the extracellular matrix mediating processes such as protein processing and extracellular matrix assembly.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nADAMTS7 functions as an important regulatory enzyme involved in the processing of cartilage oligomeric matrix protein (COMP). This process impacts the integrity and function of cartilage suggesting its vital role in maintaining cartilage homeostasis. Though it does not form part of a larger complex ADAMTS7 interacts closely with extracellular matrix components modulating cellular processes connected to tissue organization and structural integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nADAMTS7 is integral to the extracellular matrix organization pathway impacting its degradation and synthesis. It is also associated with the focal adhesion pathway which is critical for cell adhesion migration and signal transduction. In these pathways ADAMTS7 acts alongside proteins such as integrins and other matrix metalloproteinases coordinating cellular responses to mechanical and chemical stimuli through direct protein interactions.\u003cbr\u003e\nADAMTS7 has a connection to atherosclerosis and osteoarthritis. In atherosclerosis ADAMTS7 influences the remodeling of vascular tissues with effects on arterial stiffness and plaque stability. It interacts with proteins like low-density lipoprotein receptor-related protein 1 (LRP1) affecting lipid accumulation and inflammatory responses. In osteoarthritis ADAMTS7 contributes to cartilage degradation linking with other matrix-degrading enzymes to influence the progression of joint degeneration and inflammation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850068906153,"sku":"ab28557","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab28557","provider":"Iright","version":"1.0","type":"link"}