{"product_id":"abcam-ab286961","title":"Abcam, ab286961, IACS-010759","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 562.6 Da, Purity \u0026gt;98%. A potent and selective Oxidative Phosphorylation Inhibitor (IC 50  \u0026lt; 10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1570496-34-2,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:562.6 Da,\u003cbr\u003e\nMolecular formula:C25H25F3N6O4S,\u003cbr\u003e\nPubChem:86711931,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 75 mM,\u003cbr\u003e\nBiochemical name:5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole,\u003cbr\u003e\nBiological description:A potent and selective Oxidative Phosphorylation Inhibitor (IC50 \u0026lt; 10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.,\u003cbr\u003e\nCanonical smiles:CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F,\u003cbr\u003e\nInChi:InChI=1S\/C25H25F3N6O4S\/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28)31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36\/h3-9,14,21H,10-13,15H2,1-2H3,\u003cbr\u003e\nInChiKey:HWJWNWZJUYCGKV-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:5-[5-methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2231 IACS-010759. B2231-1 is the same size as the 1 mg size of ab286961.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847496093865,"sku":"ab286961","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab286961","provider":"Iright","version":"1.0","type":"link"}