{"product_id":"abcam-ab286967","title":"Abcam, ab286967, ND-630","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 569.6 Da, Purity \u0026gt;98%. A potent, and reversible acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC 50  values of 2.1 and 6.1 nM, respectively. When administered chronically to Zucker diabetic fatty rats, ND-630 reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c (0.9% reduction).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1434635-54-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:569.6 Da,\u003cbr\u003e\nMolecular formula:C28H31N3O8S,\u003cbr\u003e\nPubChem:71528744,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO,\u003cbr\u003e\nBiochemical name:Firsocostat,\u003cbr\u003e\nBiological description:A potent, and reversible acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively. When administered chronically to Zucker diabetic fatty rats, ND-630 reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c (0.9% reduction).,\u003cbr\u003e\nCanonical smiles:CC1=C(SC2=C1C(=O)N(C(=O)N2CC(C3=CC=CC=C3OC)OC4CCOCC4)C(C)(C)C(=O)O)C5=NC=CO5,\u003cbr\u003e\nIsomeric smiles:CC1=C(SC2=C1C(=O)N(C(=O)N2C[C@@H](C3=CC=CC=C3OC)OC4CCOCC4)C(C)(C)C(=O)O)C5=NC=CO5,\u003cbr\u003e\nInChi:InChI=1S\/C28H31N3O8S\/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4\/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)\/t20-\/m0\/s1,\u003cbr\u003e\nInChiKey:ZZWWXIBKLBMSCS-FQEVSTJZSA-N,\u003cbr\u003e\nIUPAC Name:2-[1-[(2R)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2248 ND-630. B2248-5 is the same size as the 5 mg size of ab286967.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAcetyl Coenzyme A Carboxylase (ACC) includes ACC alpha and ACC beta and holds an important role in lipid metabolism. These enzymes catalyze the carboxylation of acetyl-CoA to malonyl-CoA an important step in fatty acid biosynthesis. ACC alpha is about 265 kDa and is mainly found in the liver and adipose tissue while ACC beta with a mass of similar magnitude resides predominantly in muscle tissues. This local distribution highlights their specialized roles in different tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nACC enzymes are central in regulating fatty acid metabolism. They exist as part of multimeric complexes which ensures efficient catalytic activity. ACC alpha primarily drives the synthesis of fatty acids in tissues involved in energy storage and lipid production. Meanwhile ACC beta regulates fatty acid oxidation in muscle tissues by controlling malonyl-CoA levels a known inhibitor of carnitine palmitoyltransferase-1 (CPT-1) the key enzyme in mitochondrial fatty acid transport.\u003cbr\u003e\nPathways\u003cbr\u003e\nACC enzymes integrate into critical metabolic pathways linked to lipid metabolism. Key pathways include the fatty acid synthesis pathway and the malonyl-CoA pathway both closely allied with overall energy homeostasis. ACC enzymes play a part in the regulation of AMP-activated protein kinase (AMPK) an energy sensor in cells that modulates ACC activity by phosphorylation thereby balancing between anabolic and catabolic processes.\u003cbr\u003e\nACC enzymes have significant links to metabolic disorders such as obesity and diabetes. Dysregulation of ACC activity leads to altered lipid accumulation and insulin resistance contributing to these metabolic conditions. ACC is also connected to the protein sterol regulatory element-binding proteins (SREBPs) which regulate lipid homeostasis. Understanding and targeting ACC function offer potential therapeutic strategies for conditions like obesity and diabetes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847498584233,"sku":"ab286967","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab286967","provider":"Iright","version":"1.0","type":"link"}