{"product_id":"abcam-ab287089","title":"Abcam, ab287089, AMG-510","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 560.6 Da, Purity \u0026gt;98%. An orally available agent that targets the specific KRAS mutation, p.G12C, with potential anti-neoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents the expression of and\/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:2252403-56-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:560.6 Da,\u003cbr\u003e\nMolecular formula:C30H30F2N6O3,\u003cbr\u003e\nPubChem:137278711,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO,\u003cbr\u003e\nBiochemical name:Sotorasib,\u003cbr\u003e\nBiological description:An orally available agent that targets the specific KRAS mutation, p.G12C, with potential anti-neoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents the expression of and\/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells.,\u003cbr\u003e\nCanonical smiles:CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C,\u003cbr\u003e\nIsomeric smiles:C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C,\u003cbr\u003e\nInChi:InChI=1S\/C30H30F2N6O3\/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3\/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3\/t18-\/m0\/s1,\u003cbr\u003e\nInChiKey:NXQKSXLFSAEQCZ-SFHVURJKSA-N,\u003cbr\u003e\nIUPAC Name:6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2558 AMG-510. B2558-5 is the same size as the 5 mg size of ab287089.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847498354857,"sku":"ab287089","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab287089","provider":"Iright","version":"1.0","type":"link"}