{"product_id":"abcam-ab287101","title":"Abcam, ab287101, KIRA6","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 518.5 Da, Purity \u0026gt;98%. An ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC 50  = 0.6 μM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1589527-65-0,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:518.5 Da,\u003cbr\u003e\nMolecular formula:C28H25F3N6O,\u003cbr\u003e\nPubChem:73425700,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:~20 mg\/ml in DMSO,\u003cbr\u003e\nBiochemical name:1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea,\u003cbr\u003e\nBiological description:An ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 μM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.,\u003cbr\u003e\nCanonical smiles:CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F,\u003cbr\u003e\nInChi:InChI=1S\/C28H25F3N6O\/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38)34-17-8-6-7-16(15-17)28(29,30)31\/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38),\u003cbr\u003e\nInChiKey:NOHQEAFAESMMDX-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2594 KIRA6. B2594-5 is the same size as the 5 mg size of ab287101.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this product is reported to be light sensitive, Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847442845865,"sku":"ab287101","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab287101","provider":"Iright","version":"1.0","type":"link"}