{"product_id":"abcam-ab287126","title":"Abcam, ab287126, NSC-617145","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 400 Da, Purity \u0026gt;98%. An inhibitor of Werner syndrome helicase (WRN) (IC 50  = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 μM. It acts synergistically with Mitomycin C to induce double-strand breaks and chromosomal abnormalities  in vitro .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:203115-63-3,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:400 Da,\u003cbr\u003e\nMolecular formula:C13H10Cl4N2O4,\u003cbr\u003e\nPubChem:357621,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:~8 mg\/ml DMSO,\u003cbr\u003e\nBiochemical name:3,4-Dichloro-1-[3-(3,4-dichloro-2,5-dioxopyrrol-1-yl)-2,2-dimethylpropyl]pyrrole-2,5-dione,\u003cbr\u003e\nBiological description:An inhibitor of Werner syndrome helicase (WRN) (IC50 = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 μM. It acts synergistically with Mitomycin C to induce double-strand breaks and chromosomal abnormalities in vitro.,\u003cbr\u003e\nCanonical smiles:CC(C)(CN1C(=O)C(=C(C1=O)Cl)Cl)CN2C(=O)C(=C(C2=O)Cl)Cl,\u003cbr\u003e\nInChi:InChI=1S\/C13H10Cl4N2O4\/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23\/h3-4H2,1-2H3,\u003cbr\u003e\nInChiKey:PCOXPBOKDABARQ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3,4-dichloro-1-[3-(3,4-dichloro-2,5-dioxopyrrol-1-yl)-2,2-dimethylpropyl]pyrrole-2,5-dione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2664 NSC-617145. B2664-25 is the same size as the 25 mg size of ab287126.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847498256553,"sku":"ab287126","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab287126","provider":"Iright","version":"1.0","type":"link"}