{"product_id":"abcam-ab288451","title":"Abcam, ab288451, Anti-DDX3 antibody [EPR24221-72] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DDX3 antibody. Carrier free. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra) and reacts with Rat, Mouse, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24221-72,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDDX3 also known as DEAD-box helicase 3 plays an important role mechanically as an RNA helicase involved in unwinding RNA secondary structures. The protein has a mass of approximately 73 kDa and is commonly expressed in the cytoplasm and nucleus of a wide range of cell types. Other names for DDX3 include DBX CAP-Rf and DDX3X highlighting its varied functional roles across different studies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDEAD-box helicase 3 serves as a multifunctional protein that regulates gene expression and is implicated in RNA splicing transport and translation. It forms part of various ribonucleoprotein complexes influencing processes such as mRNA export and translation initiation. DDX3 often interacts with other proteins like eIF4E which further modulates translation of specific mRNAs.\u003cbr\u003e\nPathways\u003cbr\u003e\nDEAD-box helicase 3 acts as an essential component in several cellular pathways. It plays roles in the Wnt\/β-catenin signaling pathway where it can influence gene transcription important for cell fate decisions. DDX3 also participates in the innate immune response pathway interacting with proteins like MAVS to modulate antiviral defense mechanisms.\u003cbr\u003e\nDEAD-box helicase 3 has been associated with various cancers including hepatocellular carcinoma and breast cancer. Abnormal DDX3 function or expression can disrupt cell cycle regulation leading to uncontrolled cell growth. Additionally in viral infections such as Hepatitis C DDX3 interacts with viral proteins to facilitate replication showcasing its role in both promoting and hindering disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851626533033,"sku":"ab288451","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab288451","provider":"Iright","version":"1.0","type":"link"}